Chemical Constituents and Coagulation Activity of Amygdalus persica L. Flowers

Amygdalus persica L., belongs to Rosaceae family, and its flowers are used as medicine food. n-Butanol extract of A. were isolated purified with various column chromatographies, the fourteen compounds, chlorogenic acid butyl ester (1), rutin (2), protocatechuic (3), caffeic (4), 5-O-coumarroylquinic methyl (5), kaempferol-3-O-neohesperidoside (6), quercetin-3-O-β-D-glucoside (7), 3,5-dicaffeoylquinic (8), quercetin-3-O-α-L-rhamnoside (9), 5-O-coumaroylquinic (10), kaempferol-3-O-α-L-rhamnoside (11), kaempferol-3-O-β-D-galactoside (12), D-glucitol (13), multiflorin A (14), identified by spectroscopic data physical data. All compounds except compound 2 from for first time. The investigated their coagulation activity activated partial thromboplastin time (APTT), prothrombin (PT), thrombin (TT), bibrinogen (FIB) in vitro. results showed that (12) exhibited significant procoagulant activity, while (1) possessed anticoagulant